This book CCIS 2884 constitutes the refereed proceedings of the 11th China Health Information Processing Conference, CHIP 2025, held in Dongguan, China, during November 22-24, 2025. 

The 37 full papers included in this book were carefully reviewed and selected from 66 submissions. These papers have been categorized into 3 main topics: Biomedical data processing and model application, Mental health and disease prediction, and Drug prediction and Knowledge map.