Actin-Binding Proteins and Disease

dos Remedios, Cris; Chhabra, Deepak

Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.

This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.

Details

Published by: Springer

Publication Date: 2010-11-19

Format: Paperback

ISBN-13: 9781441924537

DOI: 10.1007/978-0-387-71749-4

Dimensions: 235cm x155cm

Pages: 348