Drug Metabolism and Pharmacokinetics Quick Guide

Khojasteh, Siamak Cyrus; Wong, Harvey; Hop, Cornelis E.C.A.

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Details

Published by: Springer

Publication Date: 2011-04-19

Format: Paperback

ISBN-13: 9781441956286

DOI: 10.1007/978-1-4419-5629-3

Dimensions: 203cm x127cm

Pages: 214