Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic

Gupta, Sudhir; Butcher, Eugene; Paul, William E.

This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.

Details

Published by: Springer

Publication Date: 2012-10-08

Format: Paperback

ISBN-10: 9781461352266

ISBN-13: 9781461352266

DOI: 10.1007/978-1-4615-0757-4

Dimensions: 235cm x155cm

Pages: 212