LC-MS in Drug Bioanalysis

Xu, Q. Alan; Madden, Timothy L.

Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

Details

Published by: Springer

Publication Date: 2012-07-16

Format: Hardcover

ISBN-13: 9781461438274

DOI: 10.1007/978-1-4614-3828-1

Dimensions: 235cm x155cm

Pages: 472