In this new volume in the Cell Biology and Translational Medicine series, we continue to explore the potential utility of stem cells in regenerative medicine. Amongst topics explored in this volume are recent developments in organoids,  signaling pathways in regeneration, wound healing, new insights into adipocytes, and regulatory aspects of stem cell commitment, differentiation and organogenesis in both health and disease. One goal of the series continues to be to highlight timely, often emerging, topics and novel approaches that can accelerate stem cell utility in regenerative medicine.