This book constitutes the refereed proceedings of the 53rd Applied Imagery Pattern Recognition Workshop, AIPR 2025, held in Washington, DC, USA, during October 13–14, 2025.

The 41 papers included in this volume were carefully reviewed and selected from 60 submissions. They focus on Imagery-Related challenges in Generative AI and Large Language Models, highlighting the accelerating impact of generative technologies on imagery, video, and multimodal reasoning.