The second edition of Blood Substitutes delivers a comprehensive and authoritative update on the rapidly evolving field of artificial oxygen therapeutics and next‑generation blood products. Building on the foundation of the first edition, this volume expands its scope to include the latest scientific advances and innovative approaches that are reshaping transfusion medicine. From hemoglobin‑based and perfluorocarbon‑based oxygen carriers to engineered proteins, vesicles, and nanotechnologies, the book offers an in‑depth exploration of the most promising solutions to global blood supply challenges.

A significantly expanded set of chapters on plasma, platelets, and hemostasis reflects the fast-growing importance of novel blood product development. Readers will find expert coverage of lyophilized plasma, freeze‑dried platelet hemostatic technologies, cryopreserved platelets, and the regenerative and immunologic properties of plasma-based therapies. These insights highlight both the scientific innovation and clinical potential driving the next generation of trauma, perioperative, and critical care interventions.

With contributions from leading investigators and clinician‑scientists, this edition integrates foundational biochemistry with translational research, regulatory considerations, and real-world applications. Detailed analyses of cutting-edge agents equip readers with a clear understanding of current evidence, safety profiles, and therapeutic opportunities.

Designed for a wide clinical and scientific audience, Blood Substitutes, 2nd Edition serves as an essential reference for professionals in surgery, anesthesiology, obstetrics and gynecology, trauma care, hematology/oncology, cardiology, pediatrics, critical care, and military medicine. Whether used for research, education, or clinical decision-making, this volume offers a definitive and forward‑looking guide to the future of blood replacement and oxygen biotherapeutics.

Henry Liu, MD
University of Pennsylvania Perelman School of Medicine
Anesthesiology & Critical Care Medicine
Philadelphia, PA 19104
USA

Dr. Alan David Kaye, MD, PhD, DABA, DABPM, DABIPP, FASA

Former Vice-Chancellor of Academic Affairs, Chief Academic Officer, and Provost, 

Vice Chairman, Research on Interventional Pain

Fellowship Director, Department of Anesthesiology 

Professor, Department of Pharmacology, Toxicology and Neurosciences

Tenured Professor of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, 

Pain Fellowship Program Director, 

LSU School of Medicine, 1501 Kings Hwy, Shreveport, LA 71103

Jonathan S. Jahr, MD, PhD, DABA, FASA

Professor Emeritus of Anesthesiology and Perioperative Medicine 

Emeritus Chair of the Faculty, Faculty Executive Committee, David Geffen School of Medicine at UCLA

Ronald Reagan UCLA Medical Center

757 Westwood Plaza, Suite 3325

Los Angeles, California 90095