This book presents the proceedings of the 6th International Conference of IFToMM ITALY (IFIT), held in Foligno (Perugia), Italy, on September 9–11, 2026. It includes peer-reviewed papers on the latest advances in mechanism and machine science, discussing topics such as biomechanical engineering, computational kinematics, the history of mechanism and machine science, gearing and transmissions, multi-body dynamics, robotics and mechatronics, the dynamics of machinery, tribology, vibrations, rotor dynamics, and vehicle dynamics. As a valuable up-to-date resource, it offers an essential overview of the subject for scientists and practitioners alike and inspires further investigations and research.