This book constitutes the proceedings of the 25th International Conference on Perspectives in Business Informatics Research, BIR 2026, which took place in Olten, Switzerland, in October 2026. The central theme of BIR 2026 was “Hybrid Intelligence in Business”.

The 28 full papers and 6 short papers included in the proceedings were carefully reviewed and selected from 56 submissions. They were organized in topical sections as follows: Design of Hybrid Intelligence Systems and Processes; Ethical, Responsible, and Accountable AI and Digital Trust; AI-supported Data and Knowledge Management; Alignment, Interoperability, and Openness; Smart Systems and Application Areas; Short Papers.