This book presents selected peer-reviewed papers from the International Conference on Intelligent Systems and Internet of Things (ISIoT 2026), held at the National School of Applied Sciences, Sidi Mohamed Ben Abdellah University, Fez, Morocco, on 14–15 May 2026. It provides an interdisciplinary perspective on recent advances in Intelligent Systems and IoT, combining theoretical developments with practical applications. The volume covers topics such as Artificial Intelligence, Machine Learning, IoT Networks, Embedded Systems, Cyber-Physical Systems, Smart Cities, Industrial Automation, Cybersecurity, Digital Health, and Intelligent Data Analytics. Intended for researchers, graduate students, and industry professionals, this book serves as a valuable reference for understanding current trends, innovative solutions, and emerging challenges in the development and deployment of next-generation smart and connected systems.