This book provides a detailed overview of the latest advancements in regenerative medicine for degenerative spine conditions to manage the chronic pain caused by these degenerative diseases. Edited and authored by globally recognized experts in the field, this comprehensive resource bridges critical knowledge gaps, offering insights into the latest advancements and techniques, including stem cell therapy, platelet rich plasma, orthobiologics, and tissue engineering. It explores the existing evidence, ethical considerations, and the future directions of regenerative spine and chronic pain medicine, including nanotechnology, bioprinting, and artificial intelligence. 

Dr. Abd-Elsayed is a Professor of Anesthesiology at the University of Wisconsin, Madison, Wisconsin, USA. He has published over 520 peer-reviewed manuscripts, edited over 50 books, written over 300 book chapters, and served on the editorial board of several journals. He is the editor-in-chief of PMCR. He also serves on several pain societies, he is the treasurer of the North American Neuromodulation Society (NANS), board member of the American Society of Interventional Pain Physicians (ASIPP) and the president of the Wisconsin Society of Interventional Pain Physicians (WISIPP)

Dr. Sudhir Diwan, nationally and internationally recognized as a key opinion leader in the field of pain management, is the President, Advanced Spine on Park Avenue, and attending at Lenox Hill Hospital, New York. Dr. Diwan was the former Director of the Tri-Institutional Pain Fellowship Program and Division of Pain Medicine at Ivy League Weill Medical College of Cornell University for more than a decade, where he also served as associate professor of clinical anesthesiology, and the faculty at the world renowned New York Presbyterian Hospital. Dr. Diwan has published extensively in prestigious peer-reviewed medical journals and medical books on a variety of pain management topics. He is on the Editorial Board for the journals of Pain Physician, Pain Practice, and Pain Research. Dr. Diwan is the Examiner for the Certification Board for American Board of Interventional Pain Physicians (ABIPP) and Fellow of Interventional Pain Practice (FIPP).

Dr. Ricardo Ruiz-López, MD, Neurosurg., FIPP, attended Medical College followed by Board certification in Neurosurgery and Internal Medicine at the Autonomous University of Madrid, Spain. He completed his fellowship in Interventional Pain Management at the Boston Pain Centre, Massachusetts General Hospital (Harvard Medical School, Massachusetts, USA) and various accredited European Universities. He is an internationally recognized expert in Interventional Pain Management, Spine Surgery, and Regenerative Medicine, with more than four decades of clinical practice, academic contribution, and professional leadership. In 1987, he founded in Barcelona one of Europe’s first pioneering multidisciplinary Interventional Pain Centers. Over nearly four decades, the center has progressively evolved into an Integrated, Advanced Outpatient Center for Spinal Care, bringing together Spine Surgery, Interventional Pain, and Regenerative Medicine within a comprehensive multidisciplinary model of care. Today, this institution operates as VERTEBRA SpinePain & Regenerative SURGERY CENTERS, providing specialized and integrated approaches to the management of complex spinal and musculoskeletal disorders. Dr. Ruiz-López in 1993, co-founded the World Institute of Pain (WIP), later serving as its President, and remains a Life Member of its Executive Board. From 2016 to 2025, he served as Founder and Program Director of the East Asia FIPP/CIPS Examination Program. He also served as Member of the drafting Committee for the Dependency Law, Ministry of Health of Spain. 2001. Dr.Ruiz-López has played a leading role in establishing national and international pain societies, chaired major European and World Pain Congresses, and served internationally as a visiting University Professor and Lecturer. Throughout his professional career, he has edited and co-edited books on the mentioned specialties and authored numerous book chapters in the fields of Minimally Invasive Spine Surgery, Interventional Pain, and Regenerative Medicine. His academic and scientific contributions include more than 600 publications, scientific presentations, lectures, and conference contributions delivered at national and international forums. His principal scientific interests focus on Minimally Invasive Spine and Interventional Pain, Regenerative Medicine, Orthobiologics including research and clinical practice with Autologous Mesenchymal Stem/Stromal cell therapies for degenerative spinal and joint disorders. He is also co-owner of patented innovations (US Patent Agency) in directional radiofrequency technology and percutaneous lumbar spine procedures.

Dr. Swarnima Vardhan is a Pain Physician with clinical, research, and academic experience spanning India and the United States. She completed her postgraduate training in Anesthesiology followed by advanced training in Pain Medicine in India. She subsequently moved to the United States, where she has continued her clinical and academic work in pain medicine, including experience in multidisciplinary pain care and pain research.

Her primary academic and clinical focus centers on interventional pain management, spine disorders, neuromodulation, regenerative medicine, and evidence-based approaches to chronic pain. She has authored peer-reviewed publications and book chapters on regenerative medicine, platelet-rich plasma, dorsal root ganglion stimulation, and neuromodulation. Her work has been featured at several prestigious national and international conferences.