This book constitutes the refereed proceedings of the Third EAI International Conference on Safe, Secure, Ethical, Responsible Technologies and Emerging Applications, SAFER-TEA 2025, held in Cape Town, South Africa, during December 8–10, 2025.

The 27 full papers included in this book were carefully reviewed and selected from 69 submissions. They were organized in topical sections as follows: Secure Critical Infrastructures,Connectivity and Cloud Systems; Cybersecurity, Privacy, Blockchain and Digital Trust; Responsible AI, Machine Learning and Data Science for Societal Decision-Making; Ethical Digital Health and Human-Centered Smart Technologies; Responsible Digital Transformation, Inclusive Education and Innovation.