SpringerBriefs in Biochemistry and Molecular Biology: Regulation of Eukaryotic Gene Expression

Barrett, Lucy W.; Fletcher, Sue; Wilton, Steve D.

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Details

Published by: Springer

Publication Date: 2013-07-09

Format: Paperback

ISBN-13: 9783034806787

DOI: 10.1007/978-3-0348-0679-4

Dimensions: 235cm x155cm

Pages: 56