The book summarizes topical knowledge about inhalation studies using controlled clinical facilities. Methodologic problems, ethical questions, new experimental approaches are addressed as well as administrative demands and risk assessment Methods applied in the classical field of inhalation toxicology - human and animal studies - are presented. Immunological or very new in vitro methods are also considered. As a monograph - and congress proceedings volume - the book contains contributions from about 20 leading scientists in the field of inhalation toxicology and particularly in clinical inhalation.