Milestones in Drug Therapy

Veronese, Francesco M.

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Details

Published by: Birkhäuser

Publication Date: 2009-09-18

Format: Hardcover

ISBN-13: 9783764386788

DOI: 10.1007/978-3-7643-8679-5

Dimensions: 244cm x170cm

Pages: 290