This book explores autophagy from multiple perspectives: Basic Science, Clinical Science, Detection Methods and Protocols, and Translational Medicine. This volume focuses on clinical science. It provides a comprehensive overview of the critical role of autophagy in neurological and many other diseases. It consolidates cutting-edge research on how autophagic dysfunction contributes to the pathogenesis of Alzheimer's, Parkinson's, stroke, and epilepsy, among other disorders. This book also systematically presents core mechanisms, emerging therapeutic targets, and key experimental findings. By integrating previously scattered research into a unified framework, it serves as an essential resource for scientists, biomedical researchers, and graduate students seeking to understand this pivotal cellular process in brain health and diseases. This volume 1 focuses on the role of autophagy in neurological and major systemic diseases, with in depth coverage of neurodegenerative, neurodevelopmental, neuropsychiatric, cardiovascular, immune, infectious, endocrine, renal, hepatic, and respiratory disorders.

As a National Distinguished Expert in China, Professor Weidong Le has established an exemplary academic record through groundbreaking contributions to neuroscience. His pioneering research on neurodegenerative mechanisms has earned him eleven consecutive years on the Elsevier Highly Cited Chinese Researchers List in Neuroscience, with his publications ranking among the top 0.01% most-cited SCI papers globally in neuroscience according to ESI metrics. This exceptional citation impact reflects his leadership in exploring novel therapeutic targets for Parkinson's disease and sleep disorders.

Professor Le's clinical expertise has been recognized through numerous honors, including the 2017 Outstanding Neurologist Award for Academic Achievement and the 2018 Outstanding Liaoning Provincial Science and Technology Worker award. His translational research has directly informed clinical practice through his contributions to the Chinese Expert Consensus on Management of Sleep Disorders in Parkinson's Disease and the Diagnostic and Treatment Guidelines for Vascular Parkinsonism.

Beyond his research and clinical work, Professor Le has edited eight specialized monographs that have become essential references in neurology. His commitment to advancing scientific discourse is demonstrated through his founding and continued leadership of the eleven annual Dalian Neuroscience Summit Forum, in addition to organizing the landmark First Chinese Autophagy Congress in 2017. These initiatives have significantly shaped neuroscience research directions and facilitate international collaboration in the field.